The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor
development. Low oxygen concentration influences cellular metabolism and, thus, affects …

Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

Sepsis involves simultaneous hyperactivation of the immune system and immune paralysis,
leading to both organ dysfunction and increased susceptibility to secondary infections. Acute …

Genes in which germline mutations confer highly or moderately increased risks of cancer
are called cancer predisposition genes. More than 100 of these genes have been identified …

Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …

Paragangliomas are neuroendocrine tumors frequently associated with mutations in RET,
NF1, VHL, and succinate dehydrogenase (SDHx) genes. Methylome analysis of a large …

The electron transport chain (ETC) couples oxidative phosphorylation (OXPHOS) with ATP
synthase to drive the generation of ATP. In immune cells, research surrounding the ETC has …

Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) is not included in the
traditional textbook schemes of the respiratory chain, reflecting the fact that it is a non …

Mitochondria of spermatozoa are different from the corresponding organelles of somatic
cells, in both their morphology and biochemistry. The biochemical differences are essentially …

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental
disorders characterized by problems with social communication, social interaction, and …