Towards Novel Biomimetic In Vitro Models of the Blood–Brain Barrier for Drug Permeability Evaluation

I Mármol, S Abizanda-Campo, JM Ayuso, I Ochoa… - Bioengineering, 2023 - mdpi.com
Current available animal and in vitro cell-based models for studying brain-related
pathologies and drug evaluation face several limitations since they are unable to reproduce …

Challenges in the development and application of organ-on-chips for intranasal drug delivery studies

M Usman Khan, X Cai, Z Shen, T Mekonnen… - Pharmaceutics, 2023 - mdpi.com
With the growing demand for the development of intranasal (IN) products, such as nasal
vaccines, which has been especially highlighted during the COVID-19 pandemic, the lack of …

Tuneable hydrogel patterns in pillarless microfluidic devices

C Olaizola-Rodrigo, S Palma-Florez, T Ranđelović… - Lab on a Chip, 2024 - pubs.rsc.org
Organ-on-chip (OOC) technology has recently emerged as a powerful tool to mimic
physiological or pathophysiological conditions through cell culture in microfluidic devices …

Real-time cell barrier monitoring by spatial transepithelial electrical resistance measurement on a microelectrode array integrated Transwell

Y Shi, S Sun, H Liu, M Zhao, M Qin, J Liu, J Hu, Y Zhao… - Lab on a Chip, 2025 - pubs.rsc.org
Transepithelial electrical resistance (TEER) measurement is a label free, rapid and real-time
technique, which is commonly used to evaluate the integrity of cell barriers. TEER …