Iron and the heart: A paradigm shift from systemic to cardiomyocyte abnormalities

A Paterek, U Mackiewicz… - Journal of cellular …, 2019 - Wiley Online Library
Iron is a key micronutrient for the human body and participates in biological processes, such
as oxygen transport, storage, and utilization. Iron homeostasis plays a crucial role in the …

Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: an update

R Gordan, S Wongjaikam, JK Gwathmey… - Heart failure …, 2018 - Springer
Iron overload cardiomyopathy (IOC) is a major cause of death in patients with diseases
associated with chronic anemia such as thalassemia or sickle cell disease after chronic …

Cardiovascular function and treatment in β-thalassemia major: a consensus statement from the American Heart Association

DJ Pennell, JE Udelson, AE Arai, B Bozkurt… - Circulation, 2013 - Am Heart Assoc
This aim of this statement is to report an expert consensus on the diagnosis and treatment of
cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover …

Absolute and functional iron deficiency in professional athletes during training and recovery

S Reinke, WR Taylor, GN Duda, S von Haehling… - International journal of …, 2012 - Elsevier
BACKGROUND: Iron deficiency (ID) is one of the most important metabolic dysfunctions.
Athletic performance depends on oxygen transport and mitochondrial efficiency, thus on …

Anemia: A significant cardiovascular mortality risk after ST-segment elevation myocardial infarction complicated by the comorbidities of hypertension and kidney …

WC Lee, HY Fang, HC Chen, CJ Chen, CH Yang… - PloS one, 2017 - journals.plos.org
Background The effect of anemia on patients with ST-segment elevation myocardial
infarction (STEMI) remains a controversial issue. The aim of this study was to explore the …

Iron deposition following chronic myocardial infarction as a substrate for cardiac electrical anomalies: initial findings in a canine model

I Cokic, A Kali, X Wang, HJ Yang, RLQ Tang… - PLoS …, 2013 - journals.plos.org
Purpose Iron deposition has been shown to occur following myocardial infarction (MI). We
investigated whether such focal iron deposition within chronic MI lead to electrical …

Iron-sensitive cardiac magnetic resonance imaging for prediction of ventricular arrhythmia risk in patients with chronic myocardial infarction: early evidence

I Cokic, A Kali, HJ Yang, R Yee, R Tang… - Circulation …, 2015 - Am Heart Assoc
Background—Recent canines studies have shown that iron deposition within chronic
myocardial infarction (CMI) influences the electric behavior of the heart. To date, the link …

Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients

D Patsourakos, KA Gatzoulis, C Aggeli… - Journal of …, 2020 - Wiley Online Library
Background The majority of beta thalassemia major (β‐TM) patients suffer from cardiac
disease, while a significant proportion of them die suddenly. Twelve‐lead and signal …

Electrocardiographic abnormalities and arrhythmic risk markers in adult patients with beta thalassemia major

M Kolios, P Korantzopoulos, AP Vlahos… - International Journal of …, 2016 - Elsevier
Background There seems to be a significant arrhythmia burden in β-thalassemia major (TM)
patients without overt cardiomyopathy. Apart from conventional electrocardiographic (ECG) …

[HTML][HTML] Diagnostic Modalities in Detecting Cardiovascular Complications of Thalassemia

PI Fianza, AA Pramono, M Ghozali, TA Sihite… - Reviews in …, 2022 - imrpress.com
Thalassemia major is the most common monogenetic disorder worldwide, manifested as
chronic hemolytic anemia. This condition leads to the need for chronic blood transfusion to …