Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …

Zinc plays an important role in cardiomyocytes, where it exists in bound and histochemically
reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through …

Iron is the most abundant trace element in the human body. Since iron can switch between
its 2-valent and 3-valent form it is essential in various physiological processes such as …

Zinc plays a critical role in many physiological processes, and disruption of zinc
homeostasis induces various disorders, such as growth retardation, osteopenia, immune …

Doxorubicin is a powerful anticancer agent used to treat a variety of human neoplasms.
However, the clinical use of doxorubicin is hampered by cardiotoxicity and effective …

Doxorubicin is a widely used anticancer drug in clinical practice for the treatment of various
human tumors. However, its administration is associated with cardiotoxicity. Administration …

Iron is an essential trace element associated with both pathologic deficiency and toxic
overload. Thus, systemic and cell iron metabolism are highly controlled processes regulated …

Increasing evidence suggests that Zn2+ acts as a second messenger capable of
transducing extracellular stimuli into intracellular signaling events. The importance of Zn2+ …

This review is aimed at providing an overview of the key hallmarks of cardiomyocytes in
physiological and pathological conditions. The main feature of cardiac tissue is the force …

Sodium-glucose cotransporter 2 (SGLT2) inhibitors showed significant effects in patients
with diabetes or metabolic syndrome (MetS) with high cardiovascular risk. Although the …