Evidence of human acute myeloid leukemia stem cells (AML LSCs) was first reported nearly
2 decades ago through the identification of rare subpopulations of engrafting cells in …

Retinoids (ie, vitamin A, all-trans retinoic acid, and related signaling molecules) induce the
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …

Delineating hierarchical cellular states, including rare intermediates and the networks of
regulatory genes that orchestrate cell-type specification, are continuing challenges for …

Intron retention (IR) is widely recognized as a consequence of mis-splicing that leads to
failed excision of intronic sequences from pre-messenger RNAs. Our bioinformatic analyses …

Although the identification of cancer stem cells as therapeutic targets is now actively being
pursued in many human malignancies, the leukemic stem cells in acute myeloid leukemia …

Xenotransplantation models represent powerful tools for the investigation of healthy and
malignant human hematopoiesis. However, current models do not fully mimic the …

The fusion oncogene, promyelocytic leukaemia (PML)–retinoic acid receptor-α (RARA),
initiates acute promyelocytic leukaemia (APL) through both a block to differentiation and …

The explosion in sequencing technologies has provided us with an instrument to describe
mammalian transcriptomes at unprecedented depths. This has revealed that alternative …

The book aims to provide an introduction to mathematical models that describe the
dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for …

Interactions of hematopoietic cells with their microenvironment control blood cell
colonization, homing and hematopoiesis. Here, we introduce larval hematopoiesis as the …