The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming

JM Gutiérrez, LO Albulescu, RH Clare, NR Casewell… - Toxins, 2021 - mdpi.com
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …

Medicinal plants with inhibitory properties against snake venoms

AM Soares, FK Ticli, S Marcussi… - Current Medicinal …, 2005 - ingentaconnect.com
Envenomations due to snake bites are commonly treated by parenteral administration of
horse or sheep-derived polyclonal antivenoms aimed at the neutralization of toxins …

Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: A comprehensive review

B Lomonte - Toxicon, 2023 - Elsevier
Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

From fangs to pharmacology: the future of snakebite envenoming therapy

AH Laustsen, M Engmark, C Milbo… - Current …, 2016 - ingentaconnect.com
The snake is the symbol of medicine due to its association with Asclepius, the Greek God of
medicine, and so with good reasons. More than 725 species of venomous snakes have …

Ethnomedical uses and pharmacological activities of most prevalent species of genus Piper in Panama: A review

AA Durant-Archibold, AI Santana, MP Gupta - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance Piperaceae is the fifth largest family of plants in Panama.
This review focuses on the ethnomedical uses of the most prevalent Panamanian species …

Trends in snakebite envenomation therapy: scientific, technological and public health considerations

JM Gutierrez, B Lomonte, G León… - Current …, 2007 - ingentaconnect.com
The therapy of snakebite envenomation has been based on the parenteral administration of
animal-derived antivenoms. Despite the success of this treatment at reducing the impact of …

Perspective on the therapeutics of anti-snake venom

I Gómez-Betancur, V Gogineni, A Salazar-Ospina… - Molecules, 2019 - mdpi.com
Snakebite envenomation is a life-threatening disease that was recently re-included as a
neglected tropical disease (NTD), affecting millions of people in tropical and subtropical …

Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations

AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …

Medicinal plants used to treat snakebite in Central America: Review and assessment of scientific evidence

P Giovannini, MJR Howes - Journal of ethnopharmacology, 2017 - Elsevier
Ethnopharmacological relevance Every year between 1.2 and 5.5 million people worldwide
are victims of snakebites, with about 400,000 left permanently injured. In Central America an …

Bioactive aristolactams from Piper umbellatum

TK Tabopda, J Ngoupayo, J Liu, AC Mitaine-Offer… - Phytochemistry, 2008 - Elsevier
Four alkaloids named piperumbellactams A–D (1–4) were isolated from branches of Piper
umbellatum together with known N-hydroxyaristolam II (5), Np-coumaroyl tyramine (6), 4 …