Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Scaffold diversity is a crucial feature of compound collections that has a huge impact on their
success in biological screenings. The synthesis of highly complex and diverse scaffolds …

Avoidance of apoptosis is critical for the development and sustained growth of tumours. The
pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but …

The myeloid leukemia cell differentiation protein (Mcl-1) is an anti-apoptotic protein of the B-
cell lymphoma 2 (Bcl-2) family, which regulates cellular apoptosis. Mcl-1 expression plays a …

The last three decades have seen significant progress in our understanding of the role of the
pro-survival protein BCL-2 and its family members in apoptosis and cancer. BCL-2 and other …

Triple negative breast cancer (TNBC) is a molecularly heterogeneous disease lacking
recurrent targetable alterations and thus therapeutic advances have been challenging. The …

Protein–protein interactions (PPIs) control many important physiological processes within
human cells. Apoptosis or programmed cell death is closely regulated by pro-and …

Proteins of the BCL-2 family control the mitochondrial pathway of apoptosis. Targeting these
proteins proves to be an attractive strategy for anticancer therapy. The biological context is …

BH3-only proteins constitute major proportion of pro-apoptotic members of B-cell lymphoma
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …

Although chaperone‐assisted protein crystallization remains a comparatively rare
undertaking, the number of crystal structures of polypeptides fused to maltose‐binding …