Metastasis is a major cause of morbidity and mortality in cancer patients. However, the
molecular and cellular mechanisms underlying the ability of cancer cells to metastasize …

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …

Glioblastoma (GBM) is the most common primary brain cancer in adults and is notoriously
difficult to treat because of its diffuse nature. We performed single-cell RNA sequencing …

Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous
system. These cells have diverse roles in the maintenance of neurological function. In the …

Transcription factors (TFs) interact with several other proteins in the process of
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly
understood. Here we identify nuclear factor IA (NFIA) as a molecular switch inducing human …

Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic
progression remain poorly understood. We isolated pure populations of cancer cells from …

Agenesis of the corpus callosum (AgCC), a failure to develop the large bundle of fibers that
connect the cerebral hemispheres, occurs in 1: 4000 individuals. Genetics, animal models …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …