Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Transmembrane potassium (K) gradients are key determinants of membrane potential that
can modulate action potentials, control muscle contractility, and influence ion channel and …

Consumption of low dietary potassium, common with ultraprocessed foods, activates the
thiazide-sensitive sodium chloride cotransporter (NCC) via the w ith no (K) lysine …

Potassium often has a negative connotation in Nephrology as patients with chronic kidney
disease (CKD) are prone to develop hyperkalaemia. Approaches to the management of …

The mammalian distal nephron is a target of highly effective antihypertensive drugs. Genetic
variants that alter its transport activity are also inherited causes of high or low blood …

The activity of the Na+-Cl-cotransporter (NCC) in the distal convoluted tubule (DCT) is finely
tuned by phosphorylation networks involving serine/threonine kinases and phosphatases …

Epidemiological and clinical observations have shown that potassium ingestion is inversely
correlated with arterial hypertension prevalence and cardiovascular mortality. The higher the …

The distal nephron of the kidney has a central role in sodium and fluid homeostasis, and
disruption of this homeostasis due to mutations of with-no-lysine kinase 1 (WNK1), WNK4 …

Kidneys continuously filter an enormous amount of sodium and adapt kidney Na+
reabsorption to match Na+ intake to maintain circulatory volume and electrolyte …

Hypertension is the largest risk factor for cardiovascular disease, the leading cause of
mortality worldwide. As blood pressure regulation is influenced by multiple physiological …