Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

Medullary thymic epithelial cells (mTECs) ectopically express thousands of peripheral-tissue
antigens (PTAs), which drive deletion or phenotypic diversion of self-reactive immature T …

Much of our knowledge regarding the interactions between epithelial tissues and the
immune system has been gathered from animal models and co-cultures with cell lines …

Cellular diversity that shapes tissue architecture and function is governed by multiple niche
signals. Nonetheless, maintaining cellular diversity in human intestinal organoids has been …

The intestine is a unique organ inhabited by a tremendous number of microorganisms.
Intestinal epithelial cells greatly contribute to the maintenance of the symbiotic relationship …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Abstract Development of immunocompetent T cells in the thymus is required for effective
defence against all types of pathogens, including viruses, bacteria and fungi. To this end, T …

Gut-innervating nociceptor sensory neurons respond to noxious stimuli by initiating
protective responses including pain and inflammation; however, their role in enteric …

Discovery and characterization of the cytokine receptor-cytokine-decoy receptor triad formed
by receptor activator of nuclear factor kappa-B ligand (RANKL)–receptor activator of NF-κB …