Prostate specific membrane antigen (PSMA) has been the subject of several studies in
recent decades as a promising molecular target for prostate cancer (PCa), in fact it is …

Background: Monodrug therapy has been used with success to fight various pathologies.
When one medicine fails, co-administration of two or more drugs at the same time may be …

Finding the ideal antimicrobial drug with improved efficacy and a safety profile that
eliminates antibiotic resistance caused by pathogens remains a difficult task. Indeed, there is …

The kappa opioid receptor (KOR) represents an attractive target for the development of
drugs as potential antidepressants, anxiolytics and analgesics. A robust computational …

Opioid like morphine and codeine are used for the management of pain, but are associated
with serious side-effects limiting their use. Wheat gluten proteins were assessed for the …

Four novel fluorinated cyclic analogues of biphalin with excellent to modest binding affinity
for μ-, δ-, and κ-receptors were synthesized. The cyclic peptides have a combination of …

Opiate alkaloids and their synthetic derivatives are still widely used in pain management,
drug addiction, and abuse. To avoid serious side effects, compounds with properly designed …

In our ongoing pursuit of CXCR4 antagonists as potential anticancer agents, we recently
developed a potent, selective, and plasma stable peptide, Ac-Arg-Ala-[d-Cys-Arg-Phe-Phe …

Aim: The conjugation of fluorescent labels to opioid peptides is an extremely challenging
task, which needs to be overcome to create new classes of probes for biological assays …

In the present contribution, we analyze the influence that C-terminal extension of short
opioid peptide sequences by organic fragments has on receptor affinity, in vivo analgesic …