Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …

As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

Opioids are effective analgesics, but their use is beset by serious side effects, including
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …

Peptide-protein interactions are involved in various fundamental cellular functions and their
identification is crucial for designing efficacious peptide therapeutics. Recently, a number of …

Efforts are ongoing to map synaptic wiring diagrams, or connectomes, to understand the
neural basis of brain function. However, chemical synapses represent only one type of …

Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …

Among other health related issues, the rising concerns on drug resistance led to look for
alternative pharmaceutical drugs that are effective both against infectious and noninfectious …

Human prefrontal cortex (hPFC) is a complex brain region involved in cognitive and
emotional processes and several psychiatric disorders. Here, we present an overview of the …

Protein-protein interactions (PPIs) are well-established as a class of promising drug targets
for their implications in a wide range of biological processes. However, drug development …