Chronic pain is a leading cause of disability globally and associated with enormous health-
care costs. The discrepancy between the extent of tissue damage and the magnitude of …

Hypersensitivity due to central pain mechanisms can influence recovery and lead to worse
clinical outcomes, but the ability of quantitative sensory testing (QST), an index of …

Background Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely
investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of …

Studies have suggested that quantitative sensory testing (QST) might hold a predictive value
for the development of chronic postoperative pain and the response to pharmacological …

Conditioned pain modulation (CPM) is a centrally processed measure of the net effect of the
descending pain pathway. This comprises both the facilitatory as well as the inhibitory effect …

Background Knee osteoarthritis (OA) is among the most common and disabling persistent
pain conditions, with increasing prevalence and impact around the globe. In the US, the …

Accumulating evidence reveal important applications of endogenous pain modulation
assessment in healthy controls and in patients in clinical settings, as dysregulations in the …

Objectives Approximately 20% of knee osteoarthritis patients undergoing total knee
arthroplasty (TKA) report chronic postoperative pain. Studies suggest that preoperative …

Valid and reliable biomarkers can play an important role in clinical trials as indicators of
biological or pathogenic processes or as a signal of treatment response. Currently, there are …

Osteoarthritis (OA) is a leading cause of chronic pain and disability in older adults, which
most commonly affects the joints of the knee, hip, and hand. To date, there are no …