Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …

Genetic testing is used widely for diagnostic, carrier and predictive testing in monogenic
diseases. Until recently, there were no genetic testing options available for multifactorial …

We sought to explore individuals' motivations for using their direct-to-consumer genetic
testing data to generate polygenic risk scores (PRSs) using a not-for-profit third-party tool …

Genome-wide association studies have led to the identification of robust statistical
associations of genetic variants with numerous brain-related traits, including neurological …

Polygenic scores (PGS) are primed for use in personalized risk assessments for common,
complex conditions and population health screening. Although there is growing evidence …

Objective: The authors investigated associations between polygenic liabilities for bipolar
disorder, major depression, and schizophrenia and episode polarity among individuals with …

BackgroundHospital-based biobanks are being increasingly considered as a resource for
translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks …

Purpose This study aimed to systematically review current models for communicating
polygenic scores (PGS) and psycho-behavioral outcomes of receiving PGSs. Methods …

Purpose As polygenic risk scores (PRS) emerge as promising tools to inform clinical care,
there is a pressing need for patient-centered evidence to guide their implementation …

Objective To describe the communication of polygenic risk scores (PRS) in the familial
breast cancer setting. Methods Consultations between genetic healthcare providers (GHP) …