Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

N Kumari, SH Choi - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
Cancer immunotherapy has emerged as a novel cancer treatment, although recent
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Targeted xCT‐mediated ferroptosis and protumoral polarization of macrophages is effective against HCC and enhances the efficacy of the anti‐PD‐1/L1 response

B Tang, J Zhu, Y Wang, W Chen, S Fang… - Advanced …, 2023 - Wiley Online Library
Tumor‐associated macrophages (TAMs) play an essential role in tumor progression,
metastasis, and antitumor immunity. Ferroptosis has attracted extensive attention for its …

Macrophage plasticity and atherosclerosis therapy

P Lin, HH Ji, YJ Li, SD Guo - Frontiers in molecular biosciences, 2021 - frontiersin.org
Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Phage display screening of therapeutic peptide for cancer targeting and therapy

PE Saw, EW Song - Protein & cell, 2019 - academic.oup.com
Recently, phage display technology has been announced as the recipient of Nobel Prize in
Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be …

Multifunctional polymeric micelles for delivery of drugs and siRNA

AM Jhaveri, VP Torchilin - Frontiers in pharmacology, 2014 - frontiersin.org
Polymeric micelles, self-assembling nano-constructs of amphiphilic copolymers with a core-
shell structure have been used as versatile carriers for delivery of drugs as well as nucleic …

Overcoming nonviral gene delivery barriers: perspective and future

CH Jones, CK Chen, A Ravikrishnan… - Molecular …, 2013 - ACS Publications
A key end goal of gene delivery research is to develop clinically relevant vectors that can be
used to combat elusive diseases such as AIDS. Despite promising engineering strategies …

[HTML][HTML] Small interfering RNA for cancer treatment: overcoming hurdles in delivery

NB Charbe, ND Amnerkar, B Ramesh… - … Pharmaceutica Sinica B, 2020 - Elsevier
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug
delivery systems are based on the difference between cancer and healthy cells. Currently …

[HTML][HTML] Exploitation of the macrophage mannose receptor (CD206) in infectious disease diagnostics and therapeutics

AK Azad, MVS Rajaram… - Journal of cytology & …, 2014 - ncbi.nlm.nih.gov
The macrophage mannose receptor (MR, CD206) is a C-type lectin expressed
predominantly by most tissue macrophages, dendritic cells and specific lymphatic or …

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

M Cieslewicz, J Tang, JL Yu, H Cao… - Proceedings of the …, 2013 - National Acad Sciences
Most current cancer therapies focus on killing malignant cells, but these cells are often
genetically unstable and can become resistant to chemotherapy. Tumor-associated …