[HTML][HTML] Multiple myeloma current treatment algorithms

SV Rajkumar, S Kumar - Blood cancer journal, 2020 - nature.com
The treatment of multiple myeloma (MM) continues to evolve rapidly with arrival of multiple
new drugs, and emerging data from randomized trials to guide therapy. Along the disease …

Systemic immunoglobulin light chain amyloidosis

G Merlini, A Dispenzieri, V Sanchorawala… - Nature reviews Disease …, 2018 - nature.com
Systemic immunoglobulin light chain amyloidosis is a protein misfolding disease caused by
the conversion of immunoglobulin light chains from their soluble functional states into highly …

2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

M Heuser, SD Freeman… - Blood, The Journal …, 2021 - ashpublications.org
Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia
(AML) that is used for prognostic, predictive, monitoring, and efficacy-response …

A large meta-analysis establishes the role of MRD negativity in long-term survival outcomes in patients with multiple myeloma

NC Munshi, H Avet-Loiseau, KC Anderson… - Blood …, 2020 - ashpublications.org
The prognostic value of minimal residual disease (MRD) for progression-free survival (PFS)
and overall survival (OS) was evaluated in a large cohort of patients with multiple myeloma …

[HTML][HTML] B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

AD Cohen, AL Garfall, EA Stadtmauer… - The Journal of …, 2019 - Am Soc Clin Investig
BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell
maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Minimal residual disease negativity using deep sequencing is a major prognostic factor in multiple myeloma

A Perrot, V Lauwers-Cances, J Corre… - Blood, The Journal …, 2018 - ashpublications.org
The introduction of novel agents has led to major improvements in clinical outcomes for
patients with multiple myeloma. To shorten evaluation times for new treatments, health …

[HTML][HTML] Prognostic and predictive biomarker developments in multiple myeloma

CT Wallington-Beddoe, RL Mynott - Journal of hematology & oncology, 2021 - Springer
New approaches to stratify multiple myeloma patients based on prognosis and therapeutic
decision-making, or prediction, are needed since patients are currently managed in a similar …

Measurable residual disease by next-generation flow cytometry in multiple myeloma

B Paiva, N Puig, MT Cedena, L Rosiñol… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Assessing measurable residual disease (MRD) has become standard with many
tumors, but the clinical meaning of MRD in multiple myeloma (MM) remains uncertain …

Addition of isatuximab to lenalidomide, bortezomib, and dexamethasone as induction therapy for newly diagnosed, transplantation-eligible patients with multiple …

H Goldschmidt, EK Mai, U Bertsch, R Fenk… - The Lancet …, 2022 - thelancet.com
Background Anti-CD38 monoclonal antibodies have consistently shown increased efficacy
when added to standard of care for patients with multiple myeloma. We aimed to assess the …