Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with
transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote …

Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene
expression by promoting large-scale transcriptional responses in various cell types and …

Background Advanced gastric cancer (GC) is a lethal malignancy, harboring recurrent
alterations in cell cycle pathway, especially the CDKN2A-CDK4/CDK6/CCND1 axis …

A renewable source of porcine macrophages derived from pluripotent stem cells (PSCs)
would be a valuable alternative to primary porcine alveolar macrophages (PAMs) in the …

Humans are unique among terrestrial mammals in our manner of walking and running,
reflecting 7 to 8 Ma of musculoskeletal evolution since diverging with the genus Pan. One …

Super-enhancers (SEs) are cis-regulatory elements of the human genome that have been
widely discussed since the discovery and origin of the term. Super-enhancers have been …

The use of CRISPR/Cas9 technology to breed polygenicmodified animals with desired traits
holds great promise in agriculture and biomedicine. However, as most studies are based on …

Understanding the genomic control of tissue-specific gene expression and regulation can
help to inform the application of genomic technologies in farm animal breeding programs …

Background Presbycusis, also referred to as age-related hearing loss (ARHL), is a condition
that results from the cumulative effects of aging on an individual's auditory capabilities …

Introduction Super-enhancers (SEs) are clusters of enhancers that act synergistically to drive
the high-level expression of genes involved in cell identity and function. Although SEs have …