Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
The ménage à trois of autophagy, lipid droplets and liver disease
Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …
building blocks that are indispensable for liver functions. Energy deficiencies are …
[HTML][HTML] Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD
DG Mashek - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …
The diversity and breadth of cancer cell fatty acid metabolism
Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …
biomass synthesis while maintaining redox balance and cellular homeostasis. These …
TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine
TMEM41B and VMP1 are integral membrane proteins of the endoplasmic reticulum (ER)
and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins …
and regulate the formation of autophagosomes, lipid droplets (LDs), and lipoproteins …
Regulation of glucose and lipid metabolism in health and disease
Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …
most abundant sterol in mammals, is a key component of cell membranes although it does …
Circadian rhythms and obesity: Timekeeping governs lipid metabolism
Almost all living organisms have evolved autoregulatory transcriptional‐translational
feedback loops that produce oscillations with a period of approximately 24‐h. These …
feedback loops that produce oscillations with a period of approximately 24‐h. These …
Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice
W Su, S Wu, Y Yang, Y Guo, H Zhang, J Su… - Nature …, 2022 - nature.com
Abstract 17β-hydroxysteroid dehydrogenase-13 is a hepatocyte-specific, lipid droplet-
associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) …
associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) …
Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols
C Dumesnil, L Vanharanta, X Prasanna… - Nature …, 2023 - nature.com
Cellular cholesterol can be metabolized to its fatty acid esters, cholesteryl esters (CEs), to be
stored in lipid droplets (LDs). With triacylglycerols (TGs), CEs represent the main neutral …
stored in lipid droplets (LDs). With triacylglycerols (TGs), CEs represent the main neutral …
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
YM Choi, D Ajjaji, KD Fleming, PP Borbat… - Nature …, 2023 - nature.com
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …