Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric
disorders in later life. Previous studies have suggested that ELS can cause profound …

Severe mental illness (SMI) is a broad category that includes schizophrenia, bipolar
disorder, and severe depression. Both genetic disposition and environmental exposures …

Background Major depression is a disabling psychiatric illness with complex origins. Life
stress (childhood adversity and recent stressful events) is a robust risk factor for depression …

Background Depression is thought to be multifactorial in etiology, including genetic and
environmental components. While a number of gene-environment interaction studies have …

Depression is a devastating psychiatric disorder caused by a combination of genetic
predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular …

Objectives: The main aims of this paper are to review and evaluate the neurobiology of the
depressive syndrome from a neurodevelopmental perspective. Methods: An English …

This systematic review reports on moderating and mediating variables in the relationship
between childhood adversity and affective disorders. Embase, MEDLINE & PsycINFO were …

The serotonin transporter polymorphism has been linked—often in interaction with
environmental adversity—to a variety of outcomes, including affective disorders. This …

Evidence that gene× environment interactions can reflect differential sensitivity to the
environmental context, rather than risk or resilience, is increasing. To test this model, we …

Background Recent studies have examined the role that the serotonergic system plays in
moderating the association between adverse childhood experiences (ACEs) and depressive …