Targeting multiple signaling pathways in cancer: The rutin therapeutic approach

Z Nouri, S Fakhri, K Nouri, CE Wallace, MH Farzaei… - Cancers, 2020 - mdpi.com
Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The
conventional therapies used in cancer prevention/treatment suffer from low efficacy …

[HTML][HTML] A comprehensive review on secondary metabolites and health-promoting effects of edible lichen

Y Zhao, M Wang, B Xu - Journal of Functional Foods, 2021 - Elsevier
Lichens have been concerned by many researchers because of their unique secondary
metabolites. However, the research on edible lichens is still lacking. This review collected …

Anticancer potential of lichens' secondary metabolites

Z Solárová, A Liskova, M Samec, P Kubatka… - Biomolecules, 2020 - mdpi.com
Lichens produce different classes of phenolic compounds, including anthraquinones,
xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed …

Natural products as important tyrosine kinase inhibitors

B Yin, DM Fang, XL Zhou, F Gao - European journal of medicinal chemistry, 2019 - Elsevier
As an important source of drugs, natural products play an important role in the discovery and
development of new drugs. More than 60% of anti-tumor drugs are closely related to natural …

Bispecific c-Met/PD-L1 CAR-T cells have enhanced therapeutic effects on hepatocellular carcinoma

W Jiang, T Li, J Guo, J Wang, L Jia, X Shi… - Frontiers in …, 2021 - frontiersin.org
T cells expressing chimeric antigen receptors, especially CD19 CAR-T cells have exhibited
effective antitumor activities in B cell malignancies, but due to several factors such as …

Lichen depsidones with biological interest

I Ureña-Vacas, E González-Burgos, PK Divakar… - Planta …, 2022 - thieme-connect.com
Depsidones are some of the most abundant secondary metabolites produced by lichens.
These compounds have aroused great pharmacological interest due to their activities as …

Bioactive lichen secondary metabolites and their presence in species from Chile

E Poulsen-Silva, F Gordillo-Fuenzalida, C Atala… - Metabolites, 2023 - mdpi.com
Lichens are symbiotic organisms composed of at least one fungal and one algal species.
They are found in different environments around the world, even in the poles and deserts …

The Natural Products and Extracts: Anti‐Triple‐Negative Breast Cancer in Vitro

H Chen, J Yang, Y Yang, J Zhang, Y Xu… - Chemistry & …, 2021 - Wiley Online Library
Triple‐negative breast cancer (TNBC) makes up 15% to 20% of all breast cancer (BC)
cases, and represents one of the most challenging malignancies to treat. For many years …

Immunotherapy for hepatocellular carcinoma

M Zhou, B Liu, J Shen - Clinical and Experimental Medicine, 2023 - Springer
Hepatocellular carcinoma (HCC), a primary malignancy of the liver, is a threat to the health
of all humans as a prevalent malignancy and is the sixth most common cancer worldwide. It …

Unraveling the pharmacological potential of lichen extracts in the context of cancer and inflammation with a broad screening approach

R Ingelfinger, M Henke, L Roser, T Ulshöfer… - Frontiers in …, 2020 - frontiersin.org
Lichen-forming fungi are symbiotic organisms that synthesize unique natural products with
potential for new drug leads. Here, we explored the pharmacological activity of six lichen …