Severe trauma is an intractable problem in healthcare. Patients have a widespread immune
system response that is complex and vital to survival. Excessive inflammatory response is …

Trauma-induced bleeding is a leading cause of preventable mortality worldwide. 1–3
Severely injured bleeding trauma patients frequently present with trauma-induced …

BACKGROUND: Congenital heart disease (CHD) is a group of complex heart defects
associated with hematologic abnormalities, including increased risk of thrombotic and …

Background Impaired ex vivo platelet aggregation is common in trauma patients. The
mechanisms driving these impairments remain incompletely understood, but functional …

Introduction: Alzheimer's disease (AD) and aging are associated with platelet hyperactivity.
However, the mechanisms underlying abnormal platelet function in AD and aging are yet …

Background: The endotheliopathy of trauma (EoT) is associated with increased mortality
following injury. Herein, we describe the plasma proteome related to EoT in order to provide …

Multi-omics approaches are being used increasingly to study physiological and
pathophysiologic processes. Proteomics specifically focuses on the study of proteins as …

The critical plasma anticoagulant protein S (PS) circulates in two functionally distinct pools:
free (anticoagulant) or bound to complement component 4b-binding protein (C4BP)(anti …

Background After severe injury, optical measures of microvascular blood flow (MBF)
decrease and do not normalize with resuscitation to normal blood pressure. These changes …

We greatly appreciate the detailed and thoughtful comments on our manuscript 'Importance
of catecholamine signaling in the development of platelet exhaustion after traumatic …