Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Abstract On May 2017, the World Health Organization recognized sepsis as a global health
priority. Sepsis profoundly perturbs immune homeostasis by initiating a complex response …

Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …

Macrophages are ancient, phagocytic immune cells thought to have their origins 500 million
years ago in metazoan phylogeny. The understanding of macrophages has evolved to …

Dendritic cells (DCs) are bone marrow derived cells which continuously seed in peripheral
tissue. During infection, DCs play an essential interface between innate and adaptive …

Sepsis is characterized by high mortality and poor prognosis and is one of the leading
causes of death among patients in the intensive care unit (ICU). In the past, drugs that block …

The dysregulated host response and organ damage following systemic infection that
characterizes a septic event predisposes individuals to a chronic immunoparalysis state …

Background Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine
therapy are a mainstay treatment for hormone receptor-positive breast cancer. While their …

To evaluate the protective effect of tanshinone IIA on sepsis using a mouse model as well as
to preliminarily explore the mechanism behind its application. The mouse model of sepsis …

Sepsis is one of the most serious health hazards. Current research suggests that the
pathogenesis of sepsis is mediated by both pathogen‐associated molecular patterns …