Bipolar disorder and immune dysfunction: epidemiological findings, proposed pathophysiology and clinical implications

JD Rosenblat, RS McIntyre - Brain sciences, 2017 - mdpi.com
Bipolar disorder (BD) is strongly associated with immune dysfunction. Replicated
epidemiological studies have demonstrated that BD has high rates of inflammatory medical …

Bipolar disorder and inflammation

JD Rosenblat, RS McIntyre - Psychiatric Clinics, 2016 - psych.theclinics.com
Methods For this narrative clinical overview, the MEDLINE/PubMed, Embase, Google
Scholar and ClinicalTrials. gov databases were searched from inception through June 2015 …

[HTML][HTML] Increased incidence of psychiatric disorders in immune-mediated inflammatory disease

RA Marrie, R Walld, JM Bolton, J Sareen… - Journal of …, 2017 - Elsevier
Objective Although psychiatric comorbidity is known to be more prevalent in immune-
mediated inflammatory diseases (IMID) than in the general population, the incidence of …

Increased burden of psychiatric disorders in rheumatoid arthritis

RA Marrie, CA Hitchon, R Walld… - Arthritis care & …, 2018 - Wiley Online Library
Objective We estimated the incidence and prevalence of depression, anxiety disorder,
bipolar disorder, and schizophrenia in a population‐based cohort with rheumatoid arthritis …

Inflammation as a neurobiological substrate of cognitive impairment in bipolar disorder: evidence, pathophysiology and treatment implications

JD Rosenblat, E Brietzke, RB Mansur… - Journal of affective …, 2015 - Elsevier
Background Bipolar disorder (BD) has been associated with cognitive impairment during
depressed, manic and euthymic periods. Inflammation has been shown to be involved in the …

Neuroimmune crosstalk in rheumatoid arthritis

D Gao, X Gao, F Yang, Q Wang - International journal of molecular …, 2022 - mdpi.com
Recent studies have demonstrated that immunological disease progression is closely
related to abnormal function of the central nervous system (CNS). Rheumatoid arthritis (RA) …

Substance use as a risk factor for bipolar disorder: a systematic review

M Lalli, K Brouillette, F Kapczinski… - Journal of psychiatric …, 2021 - Elsevier
Detecting substance use as a predictor of bipolar disorder (BD) is important for clinicians to
perform accurate and early diagnosis, as well as better manage the treatment of individuals …

[HTML][HTML] Psychiatric comorbidity increases mortality in immune-mediated inflammatory diseases

RA Marrie, R Walld, JM Bolton, J Sareen… - General hospital …, 2018 - Elsevier
Objective We determined the association between any common mental disorder (CMD:
depression, anxiety disorder, bipolar disorder) and mortality and suicide in three immune …

Are medical comorbid conditions of bipolar disorder due to immune dysfunction?

JD Rosenblat, RS McIntyre - Acta Psychiatrica Scandinavica, 2015 - Wiley Online Library
Objective Epidemiological data have shown a clear association between bipolar disorder
(BD) and medical comorbidities. The aim of this article was to assess the evidence of …

The emerging neuroimmune hypothesis of bipolar disorder: an updated overview of neuroimmune and microglial findings

A Chaves‐Filho, C Eyres, L Blöbaum… - Journal of …, 2024 - Wiley Online Library
Bipolar disorder (BD) is a severe and multifactorial disease, with onset usually in young
adulthood, which follows a progressive course throughout life. Replicated epidemiological …