Structural biology of cilia and intraflagellar transport

N Klena, G Pigino - Annual review of cell and developmental …, 2022 - annualreviews.org
Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …

The structural basis of intraflagellar transport at a glance

MA Jordan, G Pigino - Journal of cell science, 2021 - journals.biologists.com
The intraflagellar transport (IFT) system is a remarkable molecular machine used by cells to
assemble and maintain the cilium, a long organelle extending from eukaryotic cells that …

The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains

SE Lacey, HE Foster, G Pigino - Nature Structural & Molecular Biology, 2023 - nature.com
Anterograde intraflagellar transport (IFT) trains are essential for cilia assembly and
maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and …

Biochemically validated structural model of the 15‐subunit intraflagellar transport complex IFT‐B

NA Petriman, M Loureiro‐López, M Taschner… - The EMBO …, 2022 - embopress.org
Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and
sensory reception. Cilium formation requires intraflagellar transport of structural and …

IFT-A structure reveals carriages for membrane protein transport into cilia

SJ Hesketh, AG Mukhopadhyay, D Nakamura… - Cell, 2022 - cell.com
Intraflagellar transport (IFT) trains are massive molecular machines that traffic proteins
between cilia and the cell body. Each IFT train is a dynamic polymer of two large complexes …

Mechanism of IFT-A polymerization into trains for ciliary transport

S Meleppattu, H Zhou, J Dai, M Gui, A Brown - Cell, 2022 - cell.com
Intraflagellar transport (IFT) is the highly conserved process by which proteins are
transported along ciliary microtubules by a train-like polymeric assembly of IFT-A and IFT-B …

Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex

CL McCafferty, O Papoulas, MA Jordan… - Elife, 2022 - elifesciences.org
Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential
for development and homeostasis in organisms ranging from algae to vertebrates. In …

A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia

T Quidwai, J Wang, EA Hall, NA Petriman, W Leng… - Elife, 2021 - elifesciences.org
Intraflagellar transport (IFT) is a highly conserved mechanism for motor-driven transport of
cargo within cilia, but how this cargo is selectively transported to cilia is unclear …

[HTML][HTML] Intraflagellar transport trains and motors: Insights from structure

S Webb, AG Mukhopadhyay, AJ Roberts - Seminars in cell & …, 2020 - Elsevier
Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like
organelles found on the surface of virtually all human cell types. By delivering proteins to the …

Architecture of the IFT ciliary trafficking machinery and interplay between its components

K Nakayama, Y Katoh - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
Cilia and flagella serve as cellular antennae and propellers in various eukaryotic cells, and
contain specific receptors and ion channels as well as components of axonemal …