Structural biology of cilia and intraflagellar transport
Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …
The structural basis of intraflagellar transport at a glance
MA Jordan, G Pigino - Journal of cell science, 2021 - journals.biologists.com
The intraflagellar transport (IFT) system is a remarkable molecular machine used by cells to
assemble and maintain the cilium, a long organelle extending from eukaryotic cells that …
assemble and maintain the cilium, a long organelle extending from eukaryotic cells that …
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains
Anterograde intraflagellar transport (IFT) trains are essential for cilia assembly and
maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and …
maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and …
Biochemically validated structural model of the 15‐subunit intraflagellar transport complex IFT‐B
NA Petriman, M Loureiro‐López, M Taschner… - The EMBO …, 2022 - embopress.org
Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and
sensory reception. Cilium formation requires intraflagellar transport of structural and …
sensory reception. Cilium formation requires intraflagellar transport of structural and …
IFT-A structure reveals carriages for membrane protein transport into cilia
SJ Hesketh, AG Mukhopadhyay, D Nakamura… - Cell, 2022 - cell.com
Intraflagellar transport (IFT) trains are massive molecular machines that traffic proteins
between cilia and the cell body. Each IFT train is a dynamic polymer of two large complexes …
between cilia and the cell body. Each IFT train is a dynamic polymer of two large complexes …
Mechanism of IFT-A polymerization into trains for ciliary transport
Intraflagellar transport (IFT) is the highly conserved process by which proteins are
transported along ciliary microtubules by a train-like polymeric assembly of IFT-A and IFT-B …
transported along ciliary microtubules by a train-like polymeric assembly of IFT-A and IFT-B …
Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex
CL McCafferty, O Papoulas, MA Jordan… - Elife, 2022 - elifesciences.org
Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential
for development and homeostasis in organisms ranging from algae to vertebrates. In …
for development and homeostasis in organisms ranging from algae to vertebrates. In …
A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia
Intraflagellar transport (IFT) is a highly conserved mechanism for motor-driven transport of
cargo within cilia, but how this cargo is selectively transported to cilia is unclear …
cargo within cilia, but how this cargo is selectively transported to cilia is unclear …
[HTML][HTML] Intraflagellar transport trains and motors: Insights from structure
S Webb, AG Mukhopadhyay, AJ Roberts - Seminars in cell & …, 2020 - Elsevier
Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like
organelles found on the surface of virtually all human cell types. By delivering proteins to the …
organelles found on the surface of virtually all human cell types. By delivering proteins to the …
Architecture of the IFT ciliary trafficking machinery and interplay between its components
K Nakayama, Y Katoh - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
Cilia and flagella serve as cellular antennae and propellers in various eukaryotic cells, and
contain specific receptors and ion channels as well as components of axonemal …
contain specific receptors and ion channels as well as components of axonemal …