Thiazole ring—A biologically active scaffold

A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents

MF Arshad, A Alam, AA Alshammari, MB Alhazza… - Molecules, 2022 - mdpi.com
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Pyridine compounds with antimicrobial and antiviral activities

M Marinescu, CV Popa - International journal of molecular sciences, 2022 - mdpi.com
In the context of the new life-threatening COVID-19 pandemic caused by the SARS-CoV-2
virus, finding new antiviral and antimicrobial compounds is a priority in current research …

Recent advances in pyridine scaffold: Focus on chemistry, synthesis, and antibacterial activities

MB Islam, MI Islam, N Nath, TB Emran… - BioMed research …, 2023 - Wiley Online Library
Multidrug‐resistant (MDR) pathogens have created a fatal problem for human health and
antimicrobial treatment. Among the currently available antibiotics, many are inactive against …

[HTML][HTML] Novel arylazo nicotinate derivatives as effective antibacterial agents: Green synthesis, molecular modeling, and structure-activity relationship studies

MR Eletmany, MA Albalawi, RAK Alharbi… - Journal of Saudi …, 2023 - Elsevier
A series of novel arylazo nicotinates compounds, denoted as (3a-k and 5a-d) were
synthesized and characterized through the reaction of 3-oxo-arylhydrazonals with various …

Synthesis, anti-proliferative activity, gene expression, docking and DFT investigation of novel pyrazol-1-yl-thiazol-4 (5H)-one derivatives

A Aboelnaga, E Mansour, AM Fahim… - Journal of molecular …, 2022 - Elsevier
In this elucidation, the novel thaizolone derivatives 8a-n were synthesised via the reaction
between thioamide derivatives 4a, b with chloroacetic acid and the appropriate aldehyde …

Molecular guidelines for promising antimicrobial agents

M Rzycki, M Gładysiewicz-Kudrawiec, S Kraszewski - Scientific Reports, 2024 - nature.com
Antimicrobial resistance presents a pressing challenge to public health, which requires the
search for novel antimicrobial agents. Various experimental and theoretical methods are …

[HTML][HTML] Advance in green synthesis of pharmacological important heterocycles using multicomponent reactions and magnetic nanocatalysts (MNCs)

D Zeleke, T Damena - Results in Chemistry, 2024 - Elsevier
The ever-increasing environmental pollution and its health concerns appeal replacement of
conventional organic synthesis with green synthetic methodology. This review presented …

[HTML][HTML] Thiazole ring-the antimicrobial, anti-inflammatory, and anticancer active scaffold

S Hosseininezhad, A Ramazani - Arabian Journal of Chemistry, 2023 - Elsevier
Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …

Unravelling the thermodynamics and binding interactions of bovine serum albumin (BSA) with thiazole based carbohydrazide: Multi-spectroscopic, DFT and molecular …

P Rani, S Chahal, R Kataria, P Kumar, S Kumar… - Journal of Molecular …, 2022 - Elsevier
In the present manuscript, a novel 2-((4-chlorophenyl) amino)-N'-(4-(diethylamino)-2-
hydroxybenzylidene) thiazole-4-carbohydrazide (H1) has been synthesized and …