Gene drives gaining speed
E Bier - Nature Reviews Genetics, 2022 - nature.com
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
Mitigation of emerging implications of climate change on food production systems
A Gomez-Zavaglia, JC Mejuto… - Food Research …, 2020 - Elsevier
Crops, livestock and seafood are major contributors to global economy. Agriculture and
fisheries are especially dependent on climate. Thus, elevated temperatures and carbon …
fisheries are especially dependent on climate. Thus, elevated temperatures and carbon …
[HTML][HTML] A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes
In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two
alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control …
alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control …
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
Abstract Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies …
technologies for controlling vector-borne pathogen transmission. These technologies …
Vector biology meets disease control: using basic research to fight vector-borne diseases
WR Shaw, F Catteruccia - Nature microbiology, 2019 - nature.com
Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …
Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae
R Carballar-Lejarazú, C Ogaugwu… - Proceedings of the …, 2020 - National Acad Sciences
A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver
antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The …
antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The …
Development of a confinable gene drive system in the human disease vector Aedes aegypti
Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect
millions of people every year. With an escalating burden of infections and the relative failure …
millions of people every year. With an escalating burden of infections and the relative failure …
The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito
Gene drives have enormous potential for the control of insect populations of medical and
agricultural relevance. By preferentially biasing their own inheritance, gene drives can …
agricultural relevance. By preferentially biasing their own inheritance, gene drives can …
CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii
AK Yadav, C Butler, A Yamamoto… - Proceedings of the …, 2023 - National Acad Sciences
Genetic-based methods offer environmentally friendly species-specific approaches for
control of insect pests. One method, CRISPR homing gene drive that target genes essential …
control of insect pests. One method, CRISPR homing gene drive that target genes essential …
Reducing resistance allele formation in CRISPR gene drive
CRISPR homing gene drives can convert heterozygous cells with one copy of the drive
allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism …
allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism …