Anticancer peptide: Physicochemical property, functional aspect and trend in clinical application

W Chiangjong… - … journal of oncology, 2020 - spandidos-publications.com
Cancer is currently ineffectively treated using therapeutic drugs, and is also able to resist
drug action, resulting in increased side effects following drug treatment. A novel therapeutic …

Antimicrobial peptides as anticancer agents: functional properties and biological activities

AL Tornesello, A Borrelli, L Buonaguro, FM Buonaguro… - Molecules, 2020 - mdpi.com
Antimicrobial peptides (AMPs), or host defense peptides, are small cationic or amphipathic
molecules produced by prokaryotic and eukaryotic organisms that play a key role in the …

From antimicrobial to anticancer peptides. A review

D Gaspar, AS Veiga, MARB Castanho - Frontiers in microbiology, 2013 - frontiersin.org
Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many
organisms. Although AMPs have been essentially studied and developed as potential …

Peptide-based cancer therapy: opportunity and challenge

D Wu, Y Gao, Y Qi, L Chen, Y Ma, Y Li - Cancer letters, 2014 - Elsevier
Cancer is one of the leading causes of death worldwide. Conventional cancer therapies
mainly focus on mass cell killing without high specificity and often cause severe side effects …

xDeep-AcPEP: deep learning method for anticancer peptide activity prediction based on convolutional neural network and multitask learning

J Chen, HH Cheong, SWI Siu - Journal of chemical information …, 2021 - ACS Publications
Cancer is one of the leading causes of death worldwide. Conventional cancer treatment
relies on radiotherapy and chemotherapy, but both methods bring severe side effects to …

Diversity of insect antimicrobial peptides and proteins-A functional perspective: A review

I Eleftherianos, W Zhang, C Heryanto… - International Journal of …, 2021 - Elsevier
The innate immune response of insects provides a robust line of defense against pathogenic
microbes and eukaryotic parasites. It consists of two types of overlapping immune …

On the selectivity and efficacy of defense peptides with respect to cancer cells

F Harris, SR Dennison, J Singh… - Medicinal research …, 2013 - Wiley Online Library
Here, we review potential determinants of the anticancer efficacy of innate immune peptides
(ACPs) for cancer cells. These determinants include membrane‐based factors, such as …

[HTML][HTML] Arthropod venoms and cancer

TE Heinen, ABG da Veiga - Toxicon, 2011 - Elsevier
Many active principles produced by animals, plants and microorganisms have been
employed in the development of new drugs to treat diseases such as cancer. Among the …

Induction of a Peptide with Activity against a Broad Spectrum of Pathogens in the Aedes aegypti Salivary Gland, following Infection with Dengue Virus

N Luplertlop, P Surasombatpattana, S Patramool… - PLoS …, 2011 - journals.plos.org
The ultimate stage of the transmission of Dengue Virus (DENV) to man is strongly
dependent on crosstalk between the virus and the immune system of its vector Aedes …

Backbone cyclization and dimerization of LL-37-derived peptides enhance antimicrobial activity and proteolytic stability

S Gunasekera, T Muhammad, AA Strömstedt… - Frontiers in …, 2020 - frontiersin.org
Can antimicrobial activity and peptide stability of alpha-helical peptides be increased by
making them into dimers and macrocycles? Here, we explore that concept by using KR-12 …