Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

INTRODUCTION Stem cell–derived organoids are in vitro tissue and organ mimetics that
have enormous potential as models for human organ development and disease, as …

Colorectal cancer (CRC) is among the most frequent forms of cancer, and new strategies for
its prevention and therapy are urgently needed. Here we identify a metabolite signalling …

Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component
of most organoid tissue culture. However, it has limited the utility of organoids for drug …

Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …

Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …

Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …