The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …

Spinal manipulation (SMT) is commonly used for treating individuals experiencing
musculoskeletal pain. The mechanisms of SMT remain unclear; however, pain sensitivity …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

The application of economics principles to the analysis of behavior has yielded novel
insights on value and choice across contexts ranging from laboratory animal research to …

Objective. Previous vagus nerve stimulation (VNS) studies have demonstrated
antinociceptive effects, and recent noninvasive approaches, termed transcutaneous-vagus …

Background: Pulsed radiofrequency (PRF) therapy is a clinical treatment utilizing
electromagnetic energy aimed to relieve neuropathic pain. This is the first study examining …

Inflammation causes pain by shifting the balance of ionic currents in nociceptors toward
depolarization, leading to hyperexcitability. The ensemble of ion channels within the plasma …

Aliment Pharmacol Ther 2011; 33: 1113–1122 Summary Background Many patients with
gastro‐oesophageal reflux disease (GERD) are hypersensitive to heat and acid and may …