Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

After decades of research and clinical trials there is still no cure for Alzheimer's disease
(AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the …

Chemokines orchestrate leukocyte trafficking and function in health and disease.
Heterophilic interactions between chemokines in a given microenvironment may amplify …

A neoplastic tumor consists of cancer cells that interact with each other and non-cancerous
cells that support the development of the cancer. One such cell are tumor-associated …

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …

Chemokines (chemotactic cytokines) and their receptors are critical to recruitment and
positioning of cells during development and the immune response. The chemokine system …

Leucocyte recruitment is a critical component of the immune response and is central to our
ability to fight infection. Paradoxically, leucocyte recruitment is also a central component of …

CC chemokine ligand 5 (CCL5) and CCL3 are critical for immune surveillance and
inflammation. Consequently, they are linked to the pathogenesis of many inflammatory …

Highlights•Chemokine interactions with receptors trigger cell migration in immunity and
cancer.•2015 brought high-resolution insights into the structural basis of these …

Chemokines mediate diverse fundamental biological processes, including combating
infection. Multiple chemokines are expressed at the site of infection; thus chemokine synergy …