The incidence and mortality from lung cancer is decreasing in the US due to decades of
public education and tobacco control policies, but are increasing elsewhere in the world …

Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

The overall effect of an exposure on an outcome, in the presence of a mediator with which
the exposure may interact, can be decomposed into 4 components:(1) the effect of the …

Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

This review gives an account of the cigarette as a highly efficient nicotine delivery system. It
explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction …

Genotype-by-environment interaction (GEI) is a fundamental component in understanding
complex trait variation. However, it remains challenging to identify genetic variants with GEI …

Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung
carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts …

Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …

Smoking is a major risk factor in many diseases. Genome wide association studies have
linked genes for nicotine dependence and smoking behavior to increased risk of …

Nicotine sustains tobacco addiction, a major cause of disability and premature death.
Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and …