Understanding the bone in cancer metastasis

J Fornetti, AL Welm, SA Stewart - Journal of Bone and Mineral …, 2018 - academic.oup.com
The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …

Current concepts in bone metastasis, contemporary therapeutic strategies and ongoing clinical trials

AS Gdowski, A Ranjan, JK Vishwanatha - Journal of Experimental & …, 2017 - Springer
Background Elucidation of mechanisms regulating bone metastasis has progressed
significantly in recent years and this has translated to many new therapeutic options for …

[HTML][HTML] Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

Y Kfoury, N Baryawno, N Severe, S Mei, K Gustafsson… - Cancer cell, 2021 - cell.com
Bone metastases are devastating complications of cancer. They are particularly common in
prostate cancer (PCa), represent incurable disease, and are refractory to immunotherapy …

A vertebral skeletal stem cell lineage driving metastasis

J Sun, L Hu, S Bok, AR Yallowitz, M Cung… - Nature, 2023 - nature.com
Vertebral bone is subject to a distinct set of disease processes from long bones, including a
much higher rate of solid tumour metastases,,–. The basis for this distinct biology of vertebral …

Prospective comparison of the diagnostic accuracy of 18F-FDG PET/MRI, MRI, CT, and bone scintigraphy for the detection of bone metastases in the initial staging of …

NM Bruckmann, J Kirchner, L Umutlu, WP Fendler… - European …, 2021 - Springer
Objectives To compare the diagnostic performance of [18F] FDG PET/MRI, MRI, CT, and
bone scintigraphy for the detection of bone metastases in the initial staging of primary breast …

Deep convolutional neural network-based segmentation and classification of difficult to define metastatic spinal lesions in 3D CT data

J Chmelik, R Jakubicek, P Walek, J Jan… - Medical image …, 2018 - Elsevier
This paper aims to address the segmentation and classification of lytic and sclerotic
metastatic lesions that are difficult to define by using spinal 3D Computed Tomography (CT) …

Deep learning–based algorithm improved radiologists' performance in bone metastases detection on CT

S Noguchi, M Nishio, R Sakamoto, M Yakami… - European …, 2022 - Springer
Objectives To develop and evaluate a deep learning–based algorithm (DLA) for automatic
detection of bone metastases on CT. Methods This retrospective study included CT scans …

Revisiting the vertebral venous plexus–a comprehensive review of the literature

K Carpenter, T Decater, J Iwanaga, CM Maulucci… - World neurosurgery, 2021 - Elsevier
The venous drainage of the vertebral and paravertebral regions is important for a better
understanding of hematogenous disease spread. Moreover, the spine surgeon must be well …

Gender-and age-associated differences in bone marrow adipose tissue and bone marrow fat unsaturation throughout the skeleton, quantified using chemical shift …

KM Beekman, M Regenboog, AJ Nederveen… - Frontiers in …, 2022 - frontiersin.org
Bone marrow adipose tissue (BMAT) is a dynamic tissue which is associated with
osteoporosis, bone metastasis, and primary bone tumors. The aim of this study is to …

Total-body 68Ga-PSMA-11 PET/CT for bone metastasis detection in prostate cancer patients: Potential impact on bone scan guidelines

KL Pomykala, J Czernin, TR Grogan… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Our purpose was to determine the relationship between serum prostate-specific antigen
(PSA) level categories (< 5, 5–10, 10–20, and> 20 ng/mL) and the incidence of bone …