The multifaceted role of autophagy in cancer

RC Russell, KL Guan - The EMBO journal, 2022 - embopress.org
Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Role of mitochondrial quality surveillance in myocardial infarction: from bench to bedside

H Zhou, J Ren, S Toan, D Mui - Ageing Research Reviews, 2021 - Elsevier
Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

Mitophagy in degenerative joint diseases

K Sun, X Jing, J Guo, X Yao, F Guo - Autophagy, 2021 - Taylor & Francis
Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …

Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding

SJ Simmonds, I Cuijpers, S Heymans, EAV Jones - Cells, 2020 - mdpi.com
Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

Beclin-1-dependent autophagy protects the heart during sepsis

Y Sun, X Yao, QJ Zhang, M Zhu, ZP Liu, B Ci, Y Xie… - Circulation, 2018 - Am Heart Assoc
Background: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure
in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis …

Mitophagy in cancer: a tale of adaptation

M Vara-Perez, B Felipe-Abrio, P Agostinis - Cells, 2019 - mdpi.com
In the past years, we have learnt that tumors co-evolve with their microenvironment, and that
the active interaction between cancer cells and stromal cells plays a pivotal role in cancer …

Human umbilical cord mesenchymal stem cell‐derived exosomes attenuate oxygen‐glucose deprivation/reperfusion‐induced microglial pyroptosis by promoting …

Z Hu, Y Yuan, X Zhang, Y Lu, N Dong… - Oxidative medicine …, 2021 - Wiley Online Library
Background. Mesenchymal stem cell‐derived exosomes (MSC‐exos) have been recognized
as a promising therapeutic strategy for neonatal hypoxic‐ischemic brain damage (HIBD) …

The role of mitochondrial dynamics in cardiovascular diseases

M Forte, L Schirone, P Ameri, C Basso… - British journal of …, 2021 - Wiley Online Library
The process of mitochondrial dynamics is emerging as a core player in cardiovascular
homeostasis. This process refers to the co‐ordinated cycles of biogenesis, fusion, fission …

Mitochondria and inflammatory bowel diseases: toward a stratified therapeutic intervention

G Ho, AL Theiss - Annual review of physiology, 2022 - annualreviews.org
Mitochondria serve numerous critical cellular functions, rapidly responding to extracellular
stimuli and cellular demands while dynamically communicating with other organelles …

SERCA control of cell death and survival

ER Chemaly, L Troncone, D Lebeche - Cell calcium, 2018 - Elsevier
Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …