Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Cellular senescence is the inability of cells to proliferate, which has both beneficial and
detrimental effects on tissue development and homeostasis. Chronic accumulation of …

Alzheimer's disease is the most prevalent cause of dementia, which is defined by the
combined presence of amyloid and tau, but researchers are gradually moving away from the …

The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in
mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the …

Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

FOXO transcription factors are conserved regulators of longevity downstream of insulin
signaling. These transcription factors integrate signals emanating from nutrient deprivation …

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live
for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly …