Gene regulation in the immune system by long noncoding RNAs
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
A-to-I RNA editing—immune protector and transcriptome diversifier
E Eisenberg, EY Levanon - Nature Reviews Genetics, 2018 - nature.com
Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …
modifications because it not only alters the cellular fate of RNA molecules but also alters …
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
R de Reuver, S Verdonck, E Dierick, J Nemegeer… - Nature, 2022 - nature.com
The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …
RNA editing underlies genetic risk of common inflammatory diseases
A major challenge in human genetics is to identify the molecular mechanisms of trait-
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …
Nanopore native RNA sequencing of a human poly (A) transcriptome
High-throughput complementary DNA sequencing technologies have advanced our
understanding of transcriptome complexity and regulation. However, these methods lose …
understanding of transcriptome complexity and regulation. However, these methods lose …
RNAInter v4. 0: RNA interactome repository with redefined confidence scoring system and improved accessibility
J Kang, Q Tang, J He, L Li, N Yang, S Yu… - Nucleic acids …, 2022 - academic.oup.com
Establishing an RNA-associated interaction repository facilitates the system-level
understanding of RNA functions. However, as these interactions are distributed throughout …
understanding of RNA functions. However, as these interactions are distributed throughout …
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
Direct identification of A-to-I editing sites with nanopore native RNA sequencing
TA Nguyen, JWJ Heng, P Kaewsapsak, EPL Kok… - Nature …, 2022 - nature.com
Inosine is a prevalent RNA modification in animals and is formed when an adenosine is
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …
Human ADAR1 prevents endogenous RNA from triggering translational shutdown
Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …
Dynamic landscape and evolution of m6A methylation in human
H Zhang, X Shi, T Huang, X Zhao, W Chen… - Nucleic acids …, 2020 - academic.oup.com
Abstract m6A is a prevalent internal modification in mRNAs and has been linked to the
diverse effects on mRNA fate. To explore the landscape and evolution of human m6A, we …
diverse effects on mRNA fate. To explore the landscape and evolution of human m6A, we …