Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …

Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …

A major challenge in human genetics is to identify the molecular mechanisms of trait-
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …

High-throughput complementary DNA sequencing technologies have advanced our
understanding of transcriptome complexity and regulation. However, these methods lose …

Establishing an RNA-associated interaction repository facilitates the system-level
understanding of RNA functions. However, as these interactions are distributed throughout …

INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …

Inosine is a prevalent RNA modification in animals and is formed when an adenosine is
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …

Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …

Abstract m6A is a prevalent internal modification in mRNAs and has been linked to the
diverse effects on mRNA fate. To explore the landscape and evolution of human m6A, we …