Health benefits of cyanidin-3-glucoside as a potent modulator of Nrf2-mediated oxidative stress

S Rahman, S Mathew, P Nair, WS Ramadan… - …, 2021 - Springer
Berries are natural sources of anthocyanins, especially cyanidin-3-glucoside (C3G), and
exhibit significant antioxidant, antidiabetic, anti-inflammatory, and cytoprotective effects …

Role of dietary antioxidants in p53‐mediated cancer chemoprevention and tumor suppression

JPJ Merlin, HPV Rupasinghe… - … Medicine and Cellular …, 2021 - Wiley Online Library
Cancer arises through a complex interplay between genetic, behavioral, metabolic, and
environmental factors that combined trigger cellular changes that over time promote …

Current methodologies to refine bioavailability, delivery, and therapeutic efficacy of plant flavonoids in cancer treatment

CG Vazhappilly, M Amararathna, AC Cyril… - The Journal of …, 2021 - Elsevier
Over the last two decades, several advancements have been made to improve the
therapeutic efficacy of plant flavonoids, especially in cancer treatment. Factors such as low …

Biomedical properties of propolis on diverse chronic diseases and its potential applications and health benefits

N Rivera-Yañez, CR Rivera-Yañez, G Pozo-Molina… - Nutrients, 2020 - mdpi.com
The use of alternative medicine products has increased tremendously in recent decades
and it is estimated that approximately 80% of patients globally depend on them for some part …

p53: from fundamental biology to clinical applications in cancer

M Capuozzo, M Santorsola, M Bocchetti, F Perri… - Biology, 2022 - mdpi.com
Simple Summary p53 tumour suppressor gene is the most altered in cancer. Several
decades of research have established that it is of pivotal importance in prompting neoplastic …

Bcl-2 modulation in p53 signaling pathway by flavonoids: A potential strategy towards the treatment of cancer

N Rahman, H Khan, A Zia, A Khan, S Fakhri… - International journal of …, 2021 - mdpi.com
Cancer is a major cause of death, affecting human life in both developed and developing
countries. Numerous antitumor agents exist but their toxicity and low efficacy limits their …

Dietary aflatoxin B1 and antimalarial—a lumefantrine/artesunate—therapy perturbs male rat reproductive function via pro-inflammatory and oxidative mechanisms

SE Owumi, AO Umez, U Arunsi, CE Irozuru - Scientific Reports, 2023 - nature.com
We investigated the impact of Coartem™(COA) and aflatoxin B1 (AFB1) on rats'
hypothalamus, epididymis, and testis. Male rats were randomly grouped (n= 5 rats) and …

Potential protective effects of chrysin against immunotoxicity induced by diazinon

M Zeinali, A Shafaei, H Rafatpanah, A Mosavat… - Scientific Reports, 2022 - nature.com
Acute intoxication with diazinon (DZN) as a pesticide causes mortality and morbidity
annually. This study shows the impact of sub-acute toxicity of DZN 20 mg/kg and the …

Vitamin-containing antioxidant formulation reduces carcinogen-induced DNA damage through ATR/Chk1 signaling in bronchial epithelial cells in vitro

JPJ Merlin, G Dellaire, K Murphy, HPV Rupasinghe - Biomedicines, 2021 - mdpi.com
Lung cancer has the highest mortality rate worldwide and is often diagnosed at late stages,
requiring genotoxic chemotherapy with significant side effects. Cancer prevention has …

A dietary antioxidant formulation ameliorates DNA damage caused by γ-irradiation in normal human bronchial epithelial cells in vitro

JPJ Merlin, S Mathavarajah, G Dellaire, KPJ Murphy… - Antioxidants, 2022 - mdpi.com
Antioxidants can be used as radioprotectants to reduce DNA damage due to exposure to
radiation that could result in malignancies, including lung cancer. Mortality rates are …