Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

▪ Abstract Calcium-activated chloride channels (CaCCs) play important roles in cellular
physiology, including epithelial secretion of electrolytes and water, sensory transduction …

Genetic alterations of various ion channels produce heritable cardiac arrhythmias that
predispose affected individuals to sudden death. The investigation of such'channelopathies' …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Spontaneous sarcoplasmic reticulum (SR) Ca2+ release causes delayed
afterdepolarizations (DADs) via Ca2+-induced transient inward currents (I ti). However, no …

Anion transport proteins in mammalian cells participate in a wide variety of cell and
intracellular organelle functions, including regulation of electrical activity, pH, volume, and …

Ca2+-activated Cl− channels play important roles in a variety of physiological processes,
including epithelial secretion, maintenance of smooth muscle tone, and repolarization of the …

Various types of Cl− currents have been recorded in cardiac myocytes from different regions
of the heart and in different species. With few exceptions, most of these currents are not …

Purkinje cells are specialized for rapid propagation in the heart. Furthermore, Purkinje fibers
as the source as well as the perpetuator of arrhythmias is a familiar finding. This is not …