Nowadays, numerous skincare routines are used to rejuvenate aging skin. Retinoids are
one of the most popular ingredients used in antiaging treatments. Among the …

Chemotherapy-induced peripheral neuropathic pain (CIPNP)—a severe adverse effect
observed in up to 80% of patients during treatment with antineoplastic drugs—limits the …

Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …

Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

Although both persistent itch and inflammation are commonly associated with allergic
contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling …

Background Chronic itch is a highly debilitating symptom that underlies many medical
disorders with no universally effective treatments. Although unique neuronal signaling …

Emerging evidence suggests that transient receptor potential (TRP) ion channels not only
act as 'polymodal cellular sensors' on sensory neurons but are also functionally expressed …

Although acute itch has a protective role by removing irritants to avoid further damage,
chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a …

Transient receptor potential vanilloid type 1 channel (TRPV1), as a ligand-gated non-
selective cation channel, has recently been demonstrated to have wide expression in the …