Cardiac optical mapping has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well …

Optical techniques have revolutionized the investigation of cardiac cellular physiology and
advanced our understanding of basic mechanisms of electrical activity, calcium …

Small molecule fluorochromes (synonyms: biosensors, chemosensors, fluorescent probes,
vital stains) are widely used to investigate the structure, composition, physicochemical …

Rationale: Sarcoplasmic reticulum (SR) Ca2+ cycling is key to normal excitation–contraction
coupling but may also contribute to pathological cardiac alternans and arrhythmia …

Optical mapping of cardiac excitation using voltage-and calcium-sensitive dyes has allowed
a unique view into excitation wave dynamics, and facilitated scientific discovery in the …

Systematic studies of cardiac structure-function relationships to date have been hindered by
the intrinsic complexity and variability of in vivo and ex vivo model systems. Thus, we set out …

The ability to engineer biocompatible tissue is the hallmark of modern biomedical
engineering, integrating all aspects of every sub-discipline in the field. Bringing in a diverse …

Optical mapping is a powerful imaging technique widely adopted to measure membrane
potential changes and intracellular Ca2+ variations in excitable tissues using voltage …

Combined optogenetic stimulation and optical imaging permit scalable, contact-free high-
throughput probing of cellular electrophysiology and optimization of stem-cell derived …

BACKGROUND: Simultaneous optical mapping of multiple electrophysiologically relevant
parameters in living myocardium is desirable for integrative exploration of mechanisms …