The unraveling of the regulatory mechanisms that govern neuronal excitability is a major
challenge for neuroscientists worldwide. Neurotransmitters play a critical role in maintaining …

Dopamine regulates emotional behaviors, including rewarding and aversive behaviors,
through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the …

Structural plasticity of dendritic spines in the nucleus accumbens (NAc) is crucial for learning
from aversive experiences. Activation of NMDA receptors (NMDARs) stimulates Ca2+ …

Acetylcholine is a neuromodulator critical for learning and memory. The cholinesterase
inhibitor donepezil increases brain acetylcholine levels and improves Alzheimer's disease …

Dysfunctional dopamine signaling is implicated in various neuropsychological disorders.
Previously, we reported that dopamine increases D1 receptor (D1R)-expressing medium …

The N-methyl-D-aspartate receptor (NMDAR)-mediated structural plasticity of dendritic
spines plays an important role in synaptic transmission in the brain during learning and …

Introduction The KCNQ2/KCNQ3 genes encode the voltage-gated K channel underlying the
neuronal M-current, regulating neuronal excitability. Loss-of-function (LoF) variants cause …

Introduction Since the emergence of the cholinergic hypothesis of Alzheimer's disease (AD),
acetylcholine has been viewed as a mediator of learning and memory. Donepezil improves …

The increasing rates of drug misuse highlight the urgency of identifying improved
therapeutics for treatment. Most drug‐seeking behaviours that can be modelled in rodents …