[HTML][HTML] A simple and rapid HPLC-UV method for the determination of valproic acid in human plasma using microwave-assisted derivatization with phenylhydrazine …

S Kaewpradit, G Yusakul, P Rojsitthisak, C Jantarat - Heliyon, 2024 - cell.com
This study presents an efficient high-performance liquid chromatography with ultraviolet
detection (HPLC-UV) method for monitoring valproic acid (VPA) level in human plasma. This …

Tablet splitting of antiepileptic drugs in pediatric epilepsy: potential effect on plasma drug concentrations

RP Nidanapu, S Rajan, S Mahadevan, B Gitanjali - Pediatric Drugs, 2016 - Springer
Introduction Tablet splitting is the process of dividing a tablet into portions to obtain a
prescribed dose of medication. Very few studies have investigated whether split parts of a …

An electromembrane extraction–HPLC‐UV analysis for the determination of valproic acid in human plasma

S Yaripour, M Zaheri… - Journal of the Chinese …, 2018 - Wiley Online Library
In this study, an electromembrane extraction (EME) method combined with a simple HPLC‐
UV analysis was developed and validated for the determination of valproic acid in human …

Fixed Dose Combination Tablets of Aripiprazole and Divalproex Sodium: a Pilot Pharmacokinetic Study in Human Volunteers

Z Ahmed, F Subhan, S Ahmed - AAPS PharmSciTech, 2022 - Springer
A combination product of aripiprazole (antipsychotic) and divalproex sodium (mood
stabilizer) was recently developed to establish their tolerability and safety in fixed dose …

Precolumn fluorescence labelling of sodium valproate using 9-chloromethyl anthracene: Application to dosage form and spiked human plasma

MM Mabrouk, SF Hammad, MAA Hamid… - Microchemical …, 2019 - Elsevier
A new simple, sensitive and selective reversed phase precolumn fluorescence labelling
method was developed for determination of sodium valproate (Na-VLP) in bulk, tablet …

Comparative effect of divided doses of adult solid and liquid oral formulations of antiepileptic drugs in the management of pediatric epilepsy

RP Nidanapu, B Tamijarassy… - Journal of …, 2017 - journals.sagepub.com
Objective: To compare the differences in the efficacy and safety of the commonly prescribed
AEDs in the management of epilepsy in children when using divided doses of adult solid …

[PDF][PDF] Precolumn fluorescence labelling of sodium valproate using 9-chloromethyl anthracene: Application to dosage form and spiked human plasma

MH Mahana - 2019 - academia.edu
A new simple, sensitive and selective reversed phase precolumn fluorescence labelling
method was developed for determination of sodium valproate (Na-VLP) in bulk, tablet …

[PDF][PDF] BIOAVAILABILITY OF VALPROATE SUPPOSITORIES FORMULATED FOR PAEDIATRIC USE

N Todoran, A Ciurba, S Vancea, CE Vari… - …, 2017 - farmaciajournal.com
Considering that the rectal route might eliminate the time-dependent changes of valproic
acid kinetics and starting from the need to develop suppositories for paediatric use, in our …