IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …

Structured models of ontogenic, phenotypic and functional diversity have been instrumental
for a renewed understanding of the biology of immune cells, such as macrophages and …

Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical
benefits, but only a fraction of patients respond to treatment. To predict ICB response, we …

Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The
increase in the number of sublining macrophages in the synovium is an early hallmark of …

Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Infiltration by immune cells is a hallmark of most forms of malignancy. In this context, tumor-
associated macrophages (TAMs) represent key regulators of the complex interplay between …

In tissues, macrophages are exposed to metabolic, homeostatic and immunoregulatory
signals of local or systemic origin that influence their basal functions and responses to …

The mononuclear phagocytes control the body homeostasis through the involvement in
resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental …

Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to
tailor these alterations in gene expression to the requirements of the inflammatory process …

Monocytes and macrophages provide the first line of defense against pathogens. They also
initiate acquired immunity by processing and presenting antigens and provide the …