[HTML][HTML] Venous overload choroidopathy: a hypothetical framework for central serous chorioretinopathy and allied disorders

RF Spaide, CMG Cheung, H Matsumoto, S Kishi… - Progress in retinal and …, 2022 - Elsevier
In central serous chorioretinopathy (CSC), the macula is detached because of fluid leakage
at the level of the retinal pigment epithelium. The fluid appears to originate from choroidal …

Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars

ZS Patel, TJ Brunstetter, WJ Tarver, AM Whitmire… - npj …, 2020 - nature.com
NASA's plans for space exploration include a return to the Moon to stay—boots back on the
lunar surface with an orbital outpost. This station will be a launch point for voyages to …

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

FE Garrett-Bakelman, M Darshi, SJ Green, RC Gur… - Science, 2019 - science.org
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …

Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

AG Lee, TH Mader, CR Gibson, W Tarver, P Rabiei… - npj …, 2020 - nature.com
Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual
physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity …

Scleral structure and biomechanics

C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen… - Progress in retinal and …, 2020 - Elsevier
As the eye's main load-bearing connective tissue, the sclera is centrally important to vision.
In addition to cooperatively maintaining refractive status with the cornea, the sclera must …

Terrestrial health applications of visual assessment technology and machine learning in spaceflight associated neuro-ocular syndrome

J Ong, A Tavakkoli, N Zaman, SA Kamran… - npj …, 2022 - nature.com
The neuro-ocular effects of long-duration spaceflight have been termed Spaceflight
Associated Neuro-Ocular Syndrome (SANS) and are a potential challenge for future, human …

The effects of microgravity on bone structure and function

J Man, T Graham, G Squires-Donelly, AL Laslett - npj Microgravity, 2022 - nature.com
Humans are spending an increasing amount of time in space, where exposure to conditions
of microgravity causes 1–2% bone loss per month in astronauts. Through data collected …

Human pathophysiological adaptations to the space environment

GC Demontis, MM Germani, EG Caiani… - Frontiers in …, 2017 - frontiersin.org
Space is an extreme environment for the human body, where during long-term missions
microgravity and high radiation levels represent major threats to crew health. Intriguingly …

[HTML][HTML] Effects of spaceflight on astronaut brain structure as indicated on MRI

DR Roberts, MH Albrecht, HR Collins… - … England Journal of …, 2017 - Mass Medical Soc
Background There is limited information regarding the effects of spaceflight on the
anatomical configuration of the brain and on cerebrospinal fluid (CSF) spaces. Methods We …

The effect of prolonged spaceflight on cerebrospinal fluid and perivascular spaces of astronauts and cosmonauts

G Barisano, F Sepehrband… - Proceedings of the …, 2022 - National Acad Sciences
Long-duration spaceflight induces changes to the brain and cerebrospinal fluid
compartments and visual acuity problems known as spaceflight-associated neuro-ocular …