Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding
hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid …

Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and …

TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC) in DNA,. The gene encoding TET2 resides at chromosome …

This review gives an account of the clinical and hematologic features of the myelodysplastic
syndromes. It supplies the latest classification of these disorders, discusses the cytogenetic …

Purpose Azacitidine (AZA) is the current standard of care for high-risk (ie, International
Prognostic Scoring System high or intermediate 2) myelodysplastic syndrome (MDS), but …

Myelodysplastic syndromes are clonal marrow stem-cell disorders, characterised by
ineffective haemopoiesis leading to blood cytopenias, and by progression to acute myeloid …

Alterations in DNA methylation have been implicated in the pathogenesis of myelodysplastic
syndromes (MDS), although the underlying mechanism remains largely unknown …

Myelodysplastic syndromes (MDS) are clonal haematopoietic stem cell (HSC) disorders
predominating in the elderly, characterised by ineffective haematopoiesis leading to blood …

Recent studies of the spectrum of somatic genetic alterations in acute myeloid leukemia
(AML) have identified frequent somatic mutations in genes that encode proteins important in …

Somatically acquired genetic abnormalities lead to the salient features that define
myelodysplastic syndromes (MDS): clonal hematopoiesis, aberrant differentiation …