Simple Summary Organometallics, such as copper compounds, are cancer
chemotherapeutics used alone or in combination with other drugs. One small group of …

DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

Being a structural and catalytic cofactor in a number of biological pathways, copper
accumulates in tumors owing to selective permeability of the cancer cell membranes …

Thiosemicarbazones are promising candidates for anticancer therapy and their mechanism
of action is often linked to their metal chelating ability. In this study, five (thio) …

Copper is an essential trace metal required by organisms to perform a number of important
biological processes. Copper readily cycles between its reduced Cu (i) and oxidised Cu (ii) …

Thiosemicarbazones are chelators of transition metals such as iron or copper whose
anticancer potency is intensively investigated. Although two compounds from this class have …

The title compound, co-crystal [(aqua)(1E, 1′ E, 2E, 2′ E)-2, 2′-(propane-1, 3-diylbis
(azaneylylidene)) bis (2-phenylacetaldehyde) dioximato] copper (II) chlorate,[Cu (HL 1) ClO …

Novel [CuL2Cl] Cl· H2O (1) and [FeL2Cl2] Cl· MeOH· CHCl3· H2O (2) complexes of (Z)-N′-
((E)-3-methyl-4-oxothiazolidin-2-ylidene) picolinohydrazonamide (L) as antitumor agents …

Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA
replication, transcription, and many other aspects of DNA metabolism. The potential anti …

Topoisomerase (Topo) accelerates cell growth and division, and has been a theoretical
target for anti-cancer drugs for decades. A series of pyridoxal thiosemicarbazone (PLT) …