Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer
L Buscail, B Bournet, P Cordelier - Nature reviews Gastroenterology & …, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common
cause of death within the next 10 years. The prognosis for this disease is poor despite …
cause of death within the next 10 years. The prognosis for this disease is poor despite …
Monitoring and adapting cancer treatment using circulating tumor DNA kinetics: Current research, opportunities, and challenges
Circulating tumor DNA (ctDNA) has emerged as a biomarker with wide-ranging applications
in cancer management. While its role in guiding precision medicine in certain tumors via …
in cancer management. While its role in guiding precision medicine in certain tumors via …
Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial
S Pant, ZA Wainberg, CD Weekes, M Furqan… - Nature medicine, 2024 - nature.com
Pancreatic and colorectal cancers are often KRAS mutated and are incurable when tumor
DNA or protein persists or recurs after curative intent therapy. Cancer vaccine ELI-002 2P …
DNA or protein persists or recurs after curative intent therapy. Cancer vaccine ELI-002 2P …
Impact of circulating tumor DNA–based detection of molecular residual disease on the conduct and design of clinical trials for solid tumors
PM Kasi, G Fehringer, H Taniguchi, N Starling… - JCO Precision …, 2022 - ascopubs.org
PURPOSE Earlier detection of cancer recurrence using circulating tumor DNA (ctDNA) to
detect molecular residual disease (MRD) has the potential to dramatically affect cancer …
detect molecular residual disease (MRD) has the potential to dramatically affect cancer …
Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation
K Wang, X Wang, Q Pan, B Zhao - Molecular cancer, 2023 - Springer
Pancreatic cancer (PC) is one of the most common malignancies. Surgical resection is a
potential curative approach for PC, but most patients are unsuitable for operations when at …
potential curative approach for PC, but most patients are unsuitable for operations when at …
Association of circulating tumor DNA with disease-free survival in breast cancer: a systematic review and meta-analysis
C Cullinane, C Fleming, DP O'Leary… - JAMA network …, 2020 - jamanetwork.com
Importance Fragmented DNA is continuously released into the circulation following
apoptosis and necrosis of both cancerous and noncancerous cells; when it is released by …
apoptosis and necrosis of both cancerous and noncancerous cells; when it is released by …
Prognostic significance of postsurgery circulating tumor DNA in nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies
Studies in multiple solid tumor types have demonstrated the prognostic significance of
ctDNA analysis after curative intent surgery. A combined analysis of data across completed …
ctDNA analysis after curative intent surgery. A combined analysis of data across completed …
Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer
S Ferguson, KS Yang, P Zelga, AS Liss… - Science …, 2022 - science.org
Tumor cell–derived extracellular vesicles (EVs) are being explored as circulating
biomarkers, but it is unclear whether bulk measurements will allow early cancer detection …
biomarkers, but it is unclear whether bulk measurements will allow early cancer detection …
The liquid biopsy for lung cancer: state of the art, limitations and future developments
D Di Capua, D Bracken-Clarke, K Ronan, AM Baird… - Cancers, 2021 - mdpi.com
Simple Summary During the development and progression of lung tumors, processes such
as necrosis and vascular invasion shed tumor cells or cellular components into various fluid …
as necrosis and vascular invasion shed tumor cells or cellular components into various fluid …
Advances in liquid biopsy technology and implications for pancreatic cancer
Pancreatic cancer is a highly aggressive malignancy with a climbing incidence. The majority
of cases are detected late, with incurable locally advanced or metastatic disease. Even in …
of cases are detected late, with incurable locally advanced or metastatic disease. Even in …