Ether lipids from archaeas in nano-drug delivery and vaccination

EL Romero, MJ Morilla - International Journal of Pharmaceutics, 2023 - Elsevier
Archaea are microorganisms more closely related to eukaryotes than bacteria. Almost 50
years after being defined as a new domain of life on earth, new species continue to be …

Interactions between macrophages and biofilm during Staphylococcus aureus-associated implant infection: difficulties and solutions

M Li, J Yu, G Guo, H Shen - Journal of Innate Immunity, 2023 - karger.com
Staphylococcus aureus (S. aureus) biofilm is the major cause of failure of implant infection
treatment that results in heavy social and economic burden on individuals, families, and …

Size and charge adaptive clustered nanoparticles targeting the biofilm microenvironment for chronic lung infection management

Y Gao, J Wang, M Chai, X Li, Y Deng, Q Jin, J Ji - ACS nano, 2020 - ACS Publications
Chronic lung infection caused by bacterial biofilms is an extremely serious clinical problem,
which can lead to the failure of antibiotic therapy. Although nanoparticles have shown great …

Advancing biofilm management through nanoformulation strategies: a review of dosage forms and administration routes

O Simsekli, I Bilinmis, S Celik, G Arık… - Journal of Drug …, 2023 - Taylor & Francis
Biofilms are complex microbial communities formed by the attachment of bacteria or fungi to
surfaces encased in a self-produced polymeric matrix. These biofilms are highly resistant to …

Liposomes-based drug delivery systems of anti-biofilm agents to combat bacterial biofilm formation

Z Makhlouf, AA Ali, MH Al-Sayah - Antibiotics, 2023 - mdpi.com
All currently approved antibiotics are being met by some degree of resistance by the
bacteria they target. Biofilm formation is one of the crucial enablers of bacterial resistance …

Hypoxia-sensitive adjuvant loaded liposomes enhance the antimicrobial activity of azithromycin via phospholipase-triggered releasing for Pseudomonas aeruginosa …

Y Rao, Y Sun, P Li, M Xu, X Chen, Y Wang… - International Journal of …, 2022 - Elsevier
Robust biofilms and the complex airway environment with thick sputum, local hypoxia and
persistent inflammation induce the intractability of chronic pulmonary infections caused by …

Lipid-based nanomedicines for the treatment of bacterial respiratory infections: Current state and new perspectives

EM Arroyo-Urea, M Lázaro-Díez, J Garmendia… - …, 2024 - Taylor & Francis
The global threat posed by antimicrobial resistance demands urgent action and the
development of effective drugs. Lower respiratory tract infections remain the deadliest …

Doxorubicin loaded thermostable nanoarchaeosomes: a next-generation drug carrier for breast cancer therapeutics

KV Babunagappan, A Seetharaman, S Ariraman… - Nanoscale …, 2024 - pubs.rsc.org
Breast cancer has a poor prognosis due to the toxic side effects associated with high doses
of chemotherapy. Liposomal drug encapsulation has resulted in clinical success in …

Thymus vulgaris essential oil+ tobramycin within nanostructured archaeolipid carriers: A new approach against Pseudomonas aeruginosa biofilms

N Perez, MJ Altube, LRS Barbosa, EL Romero… - Phytomedicine, 2022 - Elsevier
Background Pseudomonas aeruginosa biofilms in the respiratory tract of patients with an
excessive inflammatory context are difficult to eradicate. New medicines that simultaneously …

Improved stability and biological activity of bacterioruberin in nanovesicles

AT Caimi, O Yasynska, PCR Rojas, EL Romero… - Journal of Drug Delivery …, 2022 - Elsevier
Bacterioruberin (BR) is a dipolar C50 isoprenoid with 13 conjugated double bonds and four
terminals hydroxyl groups produced by most members of the Haloferacaceae family of …