Piperidine derivatives: recent advances in synthesis and pharmacological applications

NA Frolov, AN Vereshchagin - International Journal of Molecular Sciences, 2023 - mdpi.com
Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Multicomponent synthesis of highly functionalized piperidines

LS Ardakani, A Arabmarkadeh… - Synthetic …, 2021 - Taylor & Francis
Highly functionalized piperidines are a versatile class of nitrogen-containing heterocycles
which find broad applications in numerous fields such as medicinal chemistry and drug …

Sulfated titania (TiO2-SO42−) as an efficient and reusable solid acid catalyst for the multi-component synthesis of highly functionalized piperidines

S Geetha, A Thangamani, R Valliappan… - Chemical Data …, 2020 - Elsevier
An efficient and one-pot procedures have been developed for the synthesis of highly
functionalized piperidine derivatives via pseudo five-component reactions in the presence of …

An efficient method for the synthesis of 2, 4, 5-trisubstituted imidazoles using lactic acid as promoter

J Sonar, S Pardeshi, S Dokhe, R Pawar, K Kharat… - SN Applied …, 2019 - Springer
Abstract Synthesis of 2, 4, 5-trisubstituted imidazole compounds from an aromatic aldehyde,
benzil and ammonium acetate is demonstrated using biodegradable lactic acid at 160° C …

A Facile One‐Pot Solvent‐Free Synthesis, in Vitro and in Silico Studies of a Series of Tetrahydropyridine Derivatives as Breast Cancer Inhibitors

R Duraisamy, P Nagaraja, A Nizam… - …, 2023 - Wiley Online Library
Ammonium trifluoroacetate (ATA) catalysed synthesis of 1, 2, 5, 6‐tetrahydropyridine (THP)
derivatives, under eco‐friendly conditions via a facile one‐pot strategy. We have …

Effect of Methods and Catalysts on the One-pot Synthesis of Tetrahydropyridine Derivatives: A Mini-Review

A Thakur, R Bharti, R Sharma - Orbital: The Electronic Journal …, 2021 - desafioonline.ufms.br
As heterocyclic nitrogen molecules, tetrahydropyridines have been recognized as significant
constituents of many natural and synthetic compounds, many of which have interesting …

Synthesis, characterization, and antibacterial activity of novel bis (indolyl) methanes sourced from biorenewable furfurals using gluconic acid aqueous solution (GAAS) …

P Naik, GB Ashoka, AH Seikh, S Dutta - RSC advances, 2024 - pubs.rsc.org
Bis (indolyl) methanes (BIMs) are important heterocycle-containing molecular scaffolds that
show remarkable biological and pharmacological activities. This work reports the synthesis …

[PDF][PDF] Recent advances in the synthesis of highly substituted piperidine analogs with biological activities

M Mokhtary, K Mahooti - Adv. J. Chem. Sect. A, 2024 - sid.ir
Heterocyclic compounds play an important role in the pharmaceutical industry, and one of
the most common structures used in their skeletons is piperidine building blocks. Thus, the …

Design and synthesis, antimicrobial activities of 1, 2, 4-triazine derivatives as representation of a new hetrocyclic system

M Shokoohian, N Hazeri, MT Maghsoodlou… - Polycyclic Aromatic …, 2021 - Taylor & Francis
Abstract Reaction of pyridine-2-(1H)-one derivatives (diamines) and 1, 2-dicarbonyl
compounds in the adjacency of acetic acid, a solvent, inexpensive and green catalyst, at 50° …

Based on MCM nanomaterials: Recoverable metallic nanocatalysts in oxidation of sulfides and oxidative coupling of thiols

C Liu - Synthetic Communications, 2021 - Taylor & Francis
Research on sulfoxides (compounds containing S= O bond) and disulfides (compounds
containing SS bond) is an important and fundamental challenge for chemists, because these …