Animal development and lifetime potential exploit a balance between the stability and
plasticity of cellular identity. Within the nucleus, this is controlled by an interplay involving …

Within the nucleus, the interplay between lineage-specific transcription factors and
chromatin dynamics defines cellular identity. Control of this interplay is necessary to properly …

Extracellular vesicles (EVs) and their cargo microRNAs (miRNAs) are important regulators of
embryo development to the blastocyst stage and beyond. Before implantation can take …

Primordial germ cells (PGCs) undergo dramatic rearrangements to their methylome during
embryogenesis, including initial genome-wide DNA demethylation that establishes the …

Clear cell renal cell carcinoma (ccRCC) is the most common malignant tumor of the kidney.
New and reliable biomarkers are in urgent need for ccRCC diagnosis and prognosis. The …

Background The histone H3 variant CENP-A is normally tightly regulated to ensure only one
centromere exists per chromosome. Native CENP-A is often found overexpressed in human …

The chromosome periphery is a complex network of proteins and RNA molecules (many
derived from nucleoli) that covers the outer surface of chromosomes and whose function …

Abstract Introduction Centromere protein A (CENP-A), an essential centromere protein, has
been associated with high grade cancers. This study was undertaken to determine if CENP …

Tumour evolution is driven by both genetic and epigenetic changes. CENP-A, the
centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability …

Centromeres play a key role in the maintenance of genome stability to prevent
carcinogenesis and diseases. They are specialized chromosome loci essential to ensure …