Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …

Hydrazones and their derivatives are very important compounds in medicinal chemistry due
to their reported biological activity for the treatment of several diseases, like Alzheimer's …

A novel series of hydrazone derivatives were designed and synthesized. Their structures
were characterized by IR, 1 H NMR, 13 C NMR and HR-MS spectroscopic methods. The …

Halogenated inhibitors showed robust, reversible, and selective monoamine oxidase-B
(MAO-B) inhibitory efficacy in candidates that were derived from them. Our team has …

Alzheimer's disease (AD) is a progressive brain disease characterised by progressive
memory loss and cognition impairment, ultimately leading to death. There are three FDA …

A new series of 6‑chloro-N'-(substituted benzylidene) nicotinohydrazide were synthesized
via condensation reactions between the corresponding hydrazides and aldehydes. All …

Neurological illnesses are among the leading causes of mortality across the world. In the
present work, the synthesis of a new series of substituted aminothiazole derivatives (3a-e) …

A series of (S)-1-phenyl-3, 4-dihydroisoquinoline-2 (1 H)-carboxamide derivatives was
synthesized and evaluated for inhibitory activity against monoamine oxidase (MAO)-A and …

Twelve pyridazinones (T1–T12) containing the (2-fluorophenyl) piperazine moiety were
designed, synthesized, and evaluated for monoamine oxidase (MAO)-A and-B inhibitory …

Background: Monoamine oxidases (MAOs) play a crucial role during the development of
various neurodegenerative disorders. There are two MAO isozymes, MAO-A and MAO-B …